Mespirenone - CISMeF

Preferred Label : Mespirenone;

NCIt definition : A spironolactone derivative and aldosterone antagonist with diuretic activity. Mespirenone, after in vivo metabolization, inhibits aldosterone synthase (steroid 18-hydroxylase), thereby preventing the synthesis of aldosterone in addition to the synthesis of other mineralocorticoids. The blockade of aldosterone synthesis results in increased sodium and water excretion while reducing potassium excretion within the kidney. Mespirenone has a short half-life and is metabolized completely into active metabolites.;

UNII : E91TME2I23;

InChIKey : CPHJTSJQUQZOLJ-ISIDMKFXSA-N;

CAS number : 87952-98-5;

Chemical formula : C25H30O4S;

Details

Origin ID

C83938;

UMLS CUI

C0066029;

Currated CISMeF NLP mapping
- mespirenone [MeSH concept]
- mespirenone [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- mespirenone [MeSH concept]
- mespirenone [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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