Preferred Label : Lisinopril Anhydrous;
NCIt synonyms : L-Proline, 1-(N(Sup 2)-(1-Carboxy-3-Phenylpropyl)-L-Lysyl)-; 1-(N(Sup 2)-((S)-1-Carboxy-3-Phenylpropyl)-L-Lysyl)-L-Proline;
NCIt definition : The anhydrous form of the long-acting angiotensin-converting enzyme (ACE) inhibitor
lisinopril with antihypertensive activity. Lisinopril, a synthetic peptide derivative,
competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin
I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin
II and results in vasodilation. Lisinopril also decreases angiotensin II-induced aldosterone
secretion by the adrenal cortex, which leads to an increase in sodium excretion and
subsequently increases water outflow.;
UNII : 7Q3P4BS2FD;
InChIKey : RLAWWYSOJDYHDC-BZSNNMDCSA-N;
CAS number : 76547-98-3;
Chemical formula : C21H31N3O5;
ChEBI ID : CHEBI:43755;
Origin ID : C83924;
UMLS CUI : C2827257;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
