Ladirubicin - CISMeF

Preferred Label : Ladirubicin;

NCIt synonyms : Idarubicin Analog PNU-159548; 4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin;

NCIt definition : A 4-demethoxydaunorubicin (idarubicin) analog with an aziridinyl group in position C-3' and a methylsulphonyl on position C-4', with potential antineoplastic activity. Upon intravenous administration, ladirubicin alkylates guanine residues at the N7 position in the DNA major groove, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis.;

UNII : U395ERO49H;

InChIKey : VMDWTZZCNDEKIO-CBNJBKGYSA-N;

CAS number : 171047-47-5;

Molecule name : PNU-159548; FCE 28729; PNU 159548;

Chemical formula : C29H31NO11S;

Details

Origin ID

C83861;

UMLS CUI

C0910889;

Automatic exact mappings (from CISMeF team)
- 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulfonyldaunorubicin [MeSH Supplementary Concept]
- ladirubicin [MeSH concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulfonyldaunorubicin [MeSH concept]
- 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulfonyldaunorubicin [MeSH Supplementary Concept]
- ladirubicin [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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