Lacosamide - CISMeF

Preferred Label : Lacosamide;

NCIt synonyms : Erlosamide; Harkoseride; (2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide;

NCIt definition : A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.;

UNII : 563KS2PQY5;

InChIKey : VPPJLAIAVCUEMN-GFCCVEGCSA-N;

CAS number : 175481-36-4;

Drug name : Vimpat;

Molecule name : SPM 927; ADD 234037;

Chemical formula : C13H18N2O3;

PubMed : 17395176;

Details

Origin ID

C83859;

UMLS CUI

C0893761;

Automatic exact mappings (from CISMeF team)
- 2-(acetylamino)-3-methoxy-N-(phenylmethyl)-, (2R)- [MeSH concept]
- 2-(acetylamino)-3-methoxy-N-(phenylmethyl)-, (2R)- [MeSH Supplementary Concept]
- harkoseride [MeSH concept]
Currated CISMeF NLP mapping
- Lacosamide [LOINC component]
- Lacosamide [MeSH Descriptor]
- Lacosamide [ICD-11 Extension code]
- Lacosamide [SMS substance]
- Lacosamide (substance) [SNOMED CT concept]
- lacosamide [Substance BNPC]
- lacosamide [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lacosamide [LOINC component]
- Lacosamide [MeSH Descriptor]
- Lacosamide (substance) [SNOMED CT concept]
- Product containing lacosamide (medicinal product) [SNOMED CT concept]
- lacosamide [ATC Code]
- lacosamide [Substance BNPC]
- lacosamide [MeSH concept]
Validated automatic mappings to BTNT
- lacosamide [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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