NCIt definition : A broad-spectrum aminoglycoside antibiotic structurally related to gentamicin and
amikacin. Isepamicin has activity similar to amikacin but with better activity against
bacterial strains with resistance to other aminoglycosides, such as strains producing
6'-N-aminoglycoside acetyltransferase. Isepamicin is not metabolized and is excreted
via the kidneys. This agent exerts a long postantibiotic effect allowing for once
daily dosing.;