NCIt definition : A recombinant peptide chemically identical or similar to endogenous somatostatin.
Somatostatin is a cyclic tetradecapeptide regulating many endocrine and nervous system
functions. Somatostatin inhibits release of adenohypophyseal growth hormone, thyrotropin
and corticotropin, pancreatic insulin and glucagon, gastric mucosal gastrin, intestinal
mucosal secretin, and renal renin by binding to specific somatostatin receptors (SSTR),
which are cell surface G protein-coupled receptors expressed in a tissue-specific
manner.;