Vasculostatin - CISMeF

Preferred Label : Vasculostatin;

NCIt synonyms : Vstat120; Vasculostatin from BAI1;

NCIt definition : Vasculostatin (899 aa, 120 kDa) is encoded by the human BAI1 gene. This protein fragment is involved in the regulation of tumor angiogenesis.;

NCIt note : Vasculostatin is an extracellular domain in brain-specific angiogenesis inhibitor 1 that is released by cleavage at a conserved G-protein-coupled receptor proteolytic cleavage site at a serine at amino acid 927. The released molecule has an RGD integrin binding motif and five thrombospondin type 1 repeats. (Oncogene (2005) 24, 3632-3642.);

Details

Origin ID

C83192;

UMLS CUI

C1336952;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
gene_encodes_gene_product
- ADGRB1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Angiogenesis Inhibitory Protein [NCIt concept]
gene_product_has_chemical_classification
- Protein Fragment [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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