Primary Systemic Amyloidosis

Preferred Label : Primary Systemic Amyloidosis;

NCIt definition : A plasma cell neoplasm that secretes an abnormal immunoglobulin, which deposits in various tissues and forms a beta-pleated sheet structure that binds Congo red dye with characteristic birefringence. The sites of involvement include heart, liver, kidney, gut, tongue, nerves, and bone. (WHO, 2001);

Neoplastic status : Undetermined;

Details

Origin ID

C8299;

UMLS CUI

C0281479;

Automatic exact mappings (from CISMeF team)
- AL amyloidosis [ORDO Disease]
- Immunoglobulin Light-chain Amyloidosis [MeSH Descriptor]
Currated CISMeF NLP mapping
- Primary systemic amyloidosis [ORDO Disease]
- Systemic amyloidosis (disorder) [SNOMED CT concept]
- primary systemic amyloidosis [Disease (Nov.)]
- systemic amyloidosis, nos [SNOMED Notion]
Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Hepatomegaly [NCIt concept]
- Neoplastic Plasma Cells Present in Bone Marrow [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Primary systemic amyloidosis [ORDO Disease]
- primary systemic amyloidosis [Disease (Nov.)]
Validated automatic mappings to NTBT
- systemic amyloidosis [Disease (Nov.)]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Amyloid Deposition [NCIt concept]
- Apple Green Dichromism Present in Polarized Congo-Red Stained Sections [NCIt concept]
- Immunoglobulin Deposition [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Primary Lesion [NCIt concept]
- Systemic Disease [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_associated_disease
- Congestive Heart Failure [NCIt concept]
- Malabsorption Syndrome [NCIt concept]
- Multiple Myeloma [NCIt concept]
- Nephrotic Syndrome [NCIt concept]
- Neuropathy [NCIt concept]
- Renal Failure [NCIt concept]

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