Preferred Label : Lincosamide Antibiotic;
NCIt definition : Any synthetic or semi-synthetic derivative of lincomycin, first isolated from a soil
actinomycete Streptomyces lincolnensis, with antibacterial activity. Lincosamide antibiotics
bind to the 23S rRNA in the large 50S subunit of bacterial ribosomes, thereby preventing
the peptidyl-tRNA translocation from the A site to the P site. This results in peptidyl-tRNA
dissociation from ribosomes, and leads to the release of incomplete proteins, ultimately
causing cell death.;
Origin ID : C82922;
UMLS CUI : C2826567;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
