Preferred Label : Semustine;
NCIt synonyms : MeCCNU; Methyl CCNU; urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI); 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; MCCNU; 1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea; Methyl Lomustine;
NCIt related terms : methyl-CCNU; trans-Methyl-CCNU; Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI); Lomustine, methyl;
NCIt definition : A methylated derivative of carmustine with antineoplastic activity. As an alkylating
agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing
depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which
may result in cytotoxicity. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called alkylating
agents.;
UNII : 6YY7T1T567;
CAS number : 13909-09-6;
NSC code : 95441;
Codes from synonyms : NSC0095441; CDR0000046772; 464;
Origin ID : C827;
UMLS CUI : C0036637;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
