Preferred Label : Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621;
NCIt synonyms : Eg5 inhibitor ARQ 621;
NCIt related terms : ARQ-621;
NCIt definition : A small-molecule inhibitor of the kinesin-related motor protein Eg5 with potential
antineoplastic activity. Eg5 kinesin-related motor protein inhibitor ARQ 621 selectively
inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and
cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11
or kinesin spindle protein-5) is a plus-end directed kinesin motor protein involved
in the regulation of spindle dynamics, including assembly and maintenance, during
mitosis.;
UNII : UU55190C8S;
Molecule name : ARQ 621;
NCI Metathesaurus CUI : CL388484;
Origin ID : C82694;
UMLS CUI : C2826391;
Semantic type(s)
- concept_is_in_subset
