NCIt definition : A synthetic peptide cancer vaccine consisting of HLA-A2-restricted peptides derived
from glioma-associated antigens (GAA) with potential immunostimulating and antineoplastic
activities. Upon administration, HLA-A2-restricted synthetic glioma antigen peptides
vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL)
response against tumor cells expressing the corresponding GAAs, resulting in glioma
tumor cell lysis. HLA-A2 is an MHC class I molecule that presents antigenic peptides
to CD8 T cells; epitope design restricted to epitopes that bind most efficiently
to HLA-A2 may improve antigenic peptide immunogenicity.;
Semantic type(s)