Preferred Label : Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride;
NCIt synonyms : EC D-3263 HCl; EC D-3263 Hydrochloride;
NCIt related terms : D-3263 HYDROCHLORIDE;
NCIt definition : An enteric-coated orally bioavailable formulation of the hydrochloride salt of a small-molecule
agonist for transient receptor potential melastatin member 8 (TRPM8 or Trp-p8) with
potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist
D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase
in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and
the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease
dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on
prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is
normally expressed in prostate cells and appears to be overexpressed in benign prostatic
hyperplasia (BPH) and in prostate cancer.;
UNII : R82GTC01OB;
CAS number : 1008763-54-9;
NCI Metathesaurus CUI : CL411370;
Origin ID : C82660;
UMLS CUI : C2826359;
Semantic type(s)
- concept_is_in_subset
