NCIt synonyms : Pegylated rHuPH20; Pegylated Recombinant Human PH20; PEGPH20; Pegylated Recombinant Human Hyaluronidase PH20;
NCIt definition : A pegylated formulation of a recombinant form of human hyaluronidase with potential
antitumor activity. Upon intravenous administration, pegvorhyaluronidase alfa degrades
hyaluronic acid (HA) coating tumor cells, which may result in the inhibition of tumor
cell growth. In addition, the degradation of HA may result in a lowering of the interstitial
fluid pressure (IFP), allowing better penetration of chemotherapeutic agents into
the tumor bed. HA is a glycosaminoglycan found in the extracellular matrix (ECM) that
is frequently overproduced by various tumor cell types. The presence of HA in tumors
correlates with increased tumor cell growth, metastatic potential, tumor progression,
increased resistance to chemotherapeutic agents, and an elevation in tumor IFP.;
Automatic exact mappings (from CISMeF team)