Preferred Label : mRNA-Derived Prostate Cancer Vaccine CV9103;
NCIt synonyms : Messenger RNA-Derived Prostate Cancer Vaccine CV9103;
NCIt definition : A prostate cancer vaccine containing mRNAs encoding prostate specific antigen (PSA),
prostate specific membrane antigen (PSMA), prostate stem cell antigen (PSCA) and six-transmembrane
epithelial antigen of the prostate (STEAP), with potential antitumor activity. Upon
administration, mRNA-derived prostate cancer vaccine CV9103 may stimulate the immune
system to mount a cytotoxic T lymphocyte response (CTL) against PSA-, PSMA-, PSCA-
and STEAP-expressing prostate tumor cells. The mRNA used in this vaccine is modified
and formulated to have enhanced translational potency and adjuvant activities. PSA,
PSMA, PSCA and STEAP may be upregulated in prostate cancer cells; their expression
in prostate cancer has been correlated with disease progression.;
Molecule name : CV9103;
NCI Metathesaurus CUI : CL388486;
Origin ID : C82654;
UMLS CUI : C2826355;
Semantic type(s)
- concept_is_in_subset
