Preferred Label : CDC7 Kinase Inhibitor BMS-863233;
NCIt synonyms : Cell Division Cycle 7 Homolog Kinase Inhibitor BMS-863233;
NCIt related terms : BMS-863233;
NCIt definition : An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with
potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits
the activity of CDC7, which may result in the inhibition of DNA replication and mitosis,
the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation
in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed
in a variety of tumor cell types, plays an essential role in the initiation of DNA
replication by activating origins of replication.;
UNII : 8QK62S7492;
CAS number : 1169558-38-6;
Molecule name : BMS-863233; XL-413;
NCI Metathesaurus CUI : CL408681;
Origin ID : C82418;
UMLS CUI : C2826164;
Semantic type(s)
- concept_is_in_subset
- has_target
