Preferred Label : Autologous NSCLC DNA-Transfected Semi-Allogeneic Fibroblasts MRC-5 Vaccine;
NCIt synonyms : Autologous Tumor-Derived DNA-Transfected Semi-Allogeneic Fibroblasts MRC-5 Vaccine;
NCIt definition : A vaccine consisting of irradiated human fetal lung fibroblasts (Medical Research
Council 5 or MRC-5) transfected with autologous non-small cell lung cancer (NSCLC)-derived
DNA with potential immunostimulatory and antineoplastic activities. Upon administration,
autologous NSCLC DNA-transfected semi-allogeneic fibroblasts MRC-5 vaccine expresses
NSCLC tumor-associated antigens (TAAs) in addition to MHC class I-determinants and
the co-stimulatory molecule B7.1, which may induce a cytotoxic T-lymphocyte (CTL)
response against NSCLC cells. The MRC-5 cell line is a human diploid lung fibroblast
cell line extablished in 1966.;
NCI Metathesaurus CUI : CL411970;
Origin ID : C82416;
UMLS CUI : C2826162;
Semantic type(s)
- concept_is_in_subset
