Preferred Label : Rimiducid;
NCIt synonyms : 2-Piperidinecarboxylic acid, 1-(1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl)-, 1,2-Ethanediylbis(imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene(3-(3,4-dimethoxyphenyl)propylidene))
Ester, (2S-(1(R*),2R*(S*(S*(1(R*),2R*)))))-; Tacrolimus Analogue AP1903;
NCIt definition : A lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug
AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single
acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold
lower affinity. This agent is used to homodimerize the Fv-containing drug-binding
domains of genetically engineered receptors such as the iCD40 receptor of the autologous
dendritic cell vaccine BP-GMAX-CD1, resulting in receptor activation.;
UNII : H564L1W5J2;
InChIKey : GQLCLPLEEOUJQC-ZTQDTCGGSA-N;
CAS number : 195514-63-7;
Molecule name : AP-1903;
Origin ID : C82412;
UMLS CUI : C4287808;
Semantic type(s)
- concept_is_in_subset
