Ontuxizumab - CISMeF

Preferred Label : Ontuxizumab;

NCIt synonyms : Immunoglobulin G1, Anti-(Human Protein TEM1 (Tumor Endothelial Marker 1)) (Human-Mouse Monoclonal MORAb-004 Heavy Chain), Disulfide with Human-Mouse Monoclonal MORAb-004 kappa-chain, Dimer; Anti-Endosialin Monoclonal Antibody MORAb-004;

NCIt definition : A humanized IgG1 monoclonal antibody directed against human endosialin/TEM1 (tumor endothelial marker;CD248) with potential anti-angiogenic and antineoplastic activities. Ontuxizumab binds to and inhibits the activity of cell surface protein endosialin/TEM1, which may result in the inhibition of angiogenesis, tumor cell proliferation and metastasis. Endosialin/TEM1 plays a key role in angiogenesis and may be overexpressed on tumor stromal cells and endothelial cells.;

UNII : 0M2XT000YC;

CAS number : 946415-62-9;

Molecule name : MORAb-004;

Details

Origin ID

C82406;

UMLS CUI

C4743425;

Automatic exact mappings (from CISMeF team)
- ontuxizumab [MeSH concept]
Currated CISMeF NLP mapping
- ontuxizumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ontuxizumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Endosialin [NCIt concept]

Keyword's position in hierarchy(ies) :

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