Preferred Label : Autologous GM-CSF-Secreting Breast Cancer Vaccine;
NCIt definition : An autologous tumor cell vaccine containing irradiated breast cancer cells transfected
with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene with potential
antineoplastic activity. Autologous breast cancer cells are transduced ex vivo with
an adenovirus vector encoding the GM-CSF gene and irradiated and then reintroduced
into the patient. Upon repeated subcutaneous administration of the vaccine, autologous
GM-CSF-secreting breast cancer cells secrete GM-CSF, which may stimulate a tumor-specific
cytotoxic T-lymphocyte (CTL) response.;
NCI Metathesaurus CUI : CL408659;
Origin ID : C82388;
UMLS CUI : C2826141;
Semantic type(s)
- concept_is_in_subset
