Preferred Label : TSP-1 Mimetic Fusion Protein CVX-045;
NCIt synonyms : Thrombospondin-1 Mimetic Fusion Protein CVX-045;
NCIt definition : A fusion protein containing two thrombospondin (TSP-1)-derived nonamer peptides covalently
attached, via a proprietary diketone linker, to a proprietary humanized catalytic
monoclonal aldolase monoclonal antibody with potential antiangiogenic and antineoplastic
activities. The TSP-1 mimetic peptide moieties of TSP-1 mimetic fusion protein CVX-045
bind to TSP-1 receptors, such as CD36, and inhibit tumor angiogenesis, which may result
in the inhibition of tumor cell proliferation. The proprietary humanized catalytic
monoclonal aldolase monoclonal antibody contains reactive lysine residues in its binding
sites, which react covalently with compounds having a diketone function; the TSP-1
mimetic peptide moieties are then covalently attached to the diketone linkers via
a proprietary spacer.;
Molecule name : CVX-045;
NCI Metathesaurus CUI : CL408655;
Origin ID : C82384;
UMLS CUI : C2826137;
Semantic type(s)
- concept_is_in_subset
