Lurbinectedin - CISMeF

Preferred Label : Lurbinectedin;

NCIt synonyms : DNA Minor Groove Binding Agent PM01183;

NCIt definition : A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.;

UNII : 2CN60TN6ZS;

InChIKey : YDDMIZRDDREKEP-HWTBNCOESA-N;

CAS number : 497871-47-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 497871-47-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Zepzelca;

Molecule name : PM-01183;

Codes from synonyms : 26763;

Details

Origin ID

C82382;

UMLS CUI

C3898565;

Currated CISMeF NLP mapping
- Lurbinectedin (substance) [SNOMED CT concept]
- lurbinectedin [MeSH concept]
Manual BTNT mappings - CISMeF
- lurbinectedin [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lurbinectedin (substance) [SNOMED CT concept]
- Product containing lurbinectedin (medicinal product) [SNOMED CT concept]
- lurbinectedin [ATC Code]
chemical_or_drug_has_mechanism_of_action
- DNA Intercalation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Crosslinking [NCIt concept]
- DNA Synthesis Inhibition [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA [NCIt concept]
is_component_of_chemotherapy_regimen
- Lurbinectedin Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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