Preferred Label : Recombinant Saccharomyces Cerevisia-CEA(610D)-Expressing Vaccine GI-6207;
NCIt synonyms : Recombinant Saccharomyces Cerevisia-CEA 610D Expressing Vaccine GI-6207;
NCIt related terms : GI-6207;
NCIt definition : A whole, heat-killed, recombinant Saccharomyces cerevisiae yeast-based vaccine genetically
altered to express the carcinoembryonic antigen (CEA) peptide 610D with potential
immunostimulating and antineoplastic activities. Upon administration, recombinant
Saccharomyces cerevisia-CEA(610D) vaccine GI-6207 may stimulate a host cytotoxic T-lymphocyte
(CTL) response against CEA-expressing tumor cells, which may result in tumor cell
lysis. CEA, a tumor associated antigen, is overexpressed on a wide variety of human
cancer cells including colorectal, gastric, lung, breast and pancreatic cancer cells.
CEA 610D encodes for 9 amino acids (605-613) in which aspartate is substituted for
asparagine at position 610 (610D) in order to strengthen the induction of the CTL
response against CEA-expressing tumor cells.;
UNII : FIJ3OLQ3N8;
Molecule name : GI-6207;
Origin ID : C82371;
UMLS CUI : C2826130;
Semantic type(s)
- concept_is_in_subset
- has_target
