Preferred Label : Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101;
NCIt synonyms : BP-GMAX-CD1; iCD40 Receptor Pulsed Autologous Dendritic Cell Vaccine BP-GMAX-CD1;
NCIt definition : A genetically-modified autologous dendritic cell-based vaccine expressing a drug-inducible
costimulatory CD40 receptor (iCD40) with potential immunomodulating and antineoplastic
activities. Autologous dendritic cells (DCs) are genetically modified to express the
iCD40 receptor and are pulsed with the tumor antigen prostate-specific membrane antigen
(PSMA). Upon intradermal administration, these DCs accumulate in local draining lymph
nodes. Twenty-four hours after vaccination, the dimerizer agent AP1903 is administered;
AP1903 binds to and activates iCD40 receptors presented on DC surfaces, thus activating
the DCs and stimulating a cytotoxic T-lymphocyte (CTL) response against host tumor
cells that express PSMA. This delayed activation strategy optimizes DC accumulation
in local draining lymph nodes prior to DC activation. iCD40 contains a membrane-localized
cytoplasmic CD40 domain fused to a drug-binding domain.;
Molecule name : BPX-101;
NCI Metathesaurus CUI : CL408640;
Origin ID : C82361;
UMLS CUI : C2830051;
Semantic type(s)
- concept_is_in_subset
