Preferred Label : Indium In 111-DOTA-di-HSG Peptide IMP-288;
NCIt synonyms : In-111-Labeled IMP-288; In-111-Labeled Di-Histamine-Succinyl-Glycine-DOTA Peptide IMP-288; Indium In-111-DOTA-di-HSG Peptide IMP-288;
NCIt definition : A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with
the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
(DOTA) to the radionuclide indium (In) 111. After pretargeting with a bispecific monoclonal
antibody (BiMoAB) directed against both a tumor associated antigen (TAA) and the HSG
hapten-peptide, the HSG portion of administered indium-In-labeled di-HSG-DOTA peptide
IMP-288 binds the anti-HSG portion of the BiMoAB; In-111 radioisotopic activity localized
to tumor cells bearing the TAA can then be visualized scintigraphically.;
NCI Metathesaurus CUI : CL408636;
Origin ID : C82356;
UMLS CUI : C2826118;
Semantic type(s)
- concept_is_in_subset
