Preferred Label : Anti-CEA/Anti-HSG Bispecific Monoclonal Antibody TF2;
NCIt synonyms : Anti-CEA x Anti-Histamine-Succinyl-Glycine Bispecific Monoclonal Antibody TF2; Anti-CEA Anti-HSG Bispecific Monoclonal Antibody TF2;
NCIt definition : A tri-Fab bispecific monoclonal antibody (BiMoAb) divalent for the carcinoembryonic
antigen (CEA) and monovalent for histamine-succinyl-glycine (HSG) peptide-hapten.
Anti-CEA/anti-HSG bispecific monoclonal antibody TF2 binds to the tumor associated
antigen (TAA) CEA on CEA-expressing tumor cells. Subsequently, an HSG peptide-hapten
carrying a radionuclide is administered, binding to the anti-HSG binding fragment
on the BiMoAb. Depending on the characteristics of the radionuclide used, CEA-expressing
tumor cells may then be radioimaged and/or treated radioimmunotherapeutically.;
Molecule name : TF2;
NCI Metathesaurus CUI : CL408839;
Origin ID : C82355;
UMLS CUI : C2826117;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
