Preferred Label : Lutetium Lu 177-DOTA-di-HSG Peptide IMP-288;
NCIt synonyms : Lu-177-Labeled Di-Histamine-Succinyl-Glycine-DOTA Peptide IMP-288;
NCIt definition : A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with
the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
(DOTA) to the radionuclide lutetium (Lu) 177. After pretargeting with a bispecific
monoclonal antibody (BiMoAB) directed against both a tumor associated antigen (TAA)
and the HSG hapten-peptide, the HSG portion of administered Lu-177-labeled di-HSG-DOTA
peptide IMP-288 binds the anti-HSG portion of the BiMoAB; Lu-177 radioisotopic activity
localized to tumor cells bearing the TAA can then be visualized scintigraphically.;
NCI Metathesaurus CUI : CL408635;
Origin ID : C82354;
UMLS CUI : C2826116;
Semantic type(s)
- concept_is_in_subset
