Preferred Label : TLR-Directed Cationic Lipid-DNA Complex JVRS-100;
NCIt synonyms : Toll-Like Receptor-Directed Cationic Lipid-DNA Complex JVRS-100; Cationic Lipid-DNA Complex JVRS-100;
NCIt definition : A cationic lipid DNA complex (CLDC) consisting of DOTIM/cholesterol liposomes and
plasmid DNA, containing immunostimulatory CpG and non-CpG motifs, with potential immunostimulating
and antineoplastic activities. Upon systemic administration, TLR-directed cationic
lipid-DNA complex JVRS-100 enters dendritic cells (DCs) and macrophages; immunostimulatory
DNA binds to and activates Toll-like receptors (TLRs), which may result in the generation
of anti-tumor natural killer (NK) cell and T-cell responses by the innate immune system.
In addition, as a vaccine adjuvant, this agent may induce a strong cytotoxic T-lymphocyte
(CTL) response to co-administered antigen.;
Molecule name : JVRS-100;
NCI Metathesaurus CUI : CL408634;
Origin ID : C82353;
UMLS CUI : C2826115;
Semantic type(s)
- concept_is_in_subset
