NCIt definition : A myeloid proliferation occurring in newborns with Down syndrome. It is clinically
and morphologically indistinguishable from acute myeloid leukemia and is associated
with GATA1 mutations. The blasts display morphologic and immunophenotypic features
of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes
spontaneous remission.;
Alternative definition : NICHD: A myeloid proliferation occurring in newborns with Down syndrome. It is clinically
and morphologically indistinguishable from acute myeloid leukemia and is associated
with GATA1 mutations. The blasts display morphologic and immunophenotypic features
of megakaryocytic lineage. In the majority of patients, the myeloid proliferation
undergoes spontaneous remission.; PCDC: AML diagnosed within four years of a diagnosis of Transient Abnormal Myelopoiesis
Associated with Down Syndrome (a myeloid proliferation occurring in newborns with
Down syndrome). Transient Abnormal Myelopoiesis Associated with Down Syndrome is clinically
and morphologically indistinguishable from acute myeloid leukemia and is associated
with GATA1 mutations.;