Transient Abnormal Myelopoiesis Associated with Down Syndrome

Preferred Label : Transient Abnormal Myelopoiesis Associated with Down Syndrome;

NCIt synonyms : TAM;

NCIt related terms : Transient Abnormal Myelopoiesis; Transient Myeloproliferative Disorder; Transient Abnormal Myelopoiesis (TAM);

NCIt definition : A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes spontaneous remission.;

Alternative definition : NICHD: A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients, the myeloid proliferation undergoes spontaneous remission.; PCDC: AML diagnosed within four years of a diagnosis of Transient Abnormal Myelopoiesis Associated with Down Syndrome (a myeloid proliferation occurring in newborns with Down syndrome). Transient Abnormal Myelopoiesis Associated with Down Syndrome is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations.;

Neoplastic status : Malignant;

ICD-O code : 9898/1;

Détails

Origin ID

C82339;

UMLS CUI

C1834582;

Currated CISMeF NLP mapping
- Myeloproliferative syndrome, transient [OMIM Phenotype]
- Transient abnormal myelopoiesis (disorder) [SNOMED CT concept]
- Transient myeloproliferative syndrome [HPO term]
- Transient myeloproliferative syndrome [ORDO Disease]
- myeloproliferative syndrome, transient [MeSH concept]
- myeloproliferative syndrome, transient [MeSH Supplementary Concept]
- transient myeloproliferative syndrome [DO Concept]
Disease may have findings
- Complete Regression [NCIt concept]
- Leukocytosis [NCIt concept]
- Thrombocytopenia [NCIt concept]
False automatic mappings
- Myopathy, tubular aggregate, 1 [OMIM Phenotype]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Trisomy 21 [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Myeloproliferative syndrome, transient [OMIM Phenotype]
- Transient abnormal myelopoiesis (disorder) [SNOMED CT concept]
- Transient abnormal myelopoiesis (morphologic abnormality) [SNOMED CT concept]
- Transient myeloproliferative syndrome [HPO term]
- Transient myeloproliferative syndrome [ORDO Disease]
- myeloproliferative syndrome, transient [MeSH Supplementary Concept]
- myeloproliferative syndrome, transient [MeSH concept]
- transient myeloproliferative syndrome [DO Concept]
concept_is_in_subset
- AML Authorized Value Terminology [NCIt concept]
- AML Disease Characteristics Table [NCIt concept]
- AML Variable Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Thrombocytopenia [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Blast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_associated_disease
- Down Syndrome [NCIt concept]
disease_has_associated_gene
- GATA1 Gene [NCIt concept]
- GATA1 wt Allele [NCIt concept]
disease_has_finding
- Childhood Lesion [NCIt concept]
- Hereditary Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Preexisting Condition [NCIt concept]
disease_has_molecular_abnormality
- GATA1 Gene Mutation [NCIt concept]
- Germline Variation [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- GATA1 Gene [NCIt concept]

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