" /> Transient Abnormal Myelopoiesis Associated with Down Syndrome - CISMeF





Preferred Label : Transient Abnormal Myelopoiesis Associated with Down Syndrome;

NCIt synonyms : TAM;

NCIt related terms : Transient Abnormal Myelopoiesis; Transient Myeloproliferative Disorder; Transient Abnormal Myelopoiesis (TAM);

NCIt definition : A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes spontaneous remission.;

Alternative definition : NICHD: A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients, the myeloid proliferation undergoes spontaneous remission.; PCDC: AML diagnosed within four years of a diagnosis of Transient Abnormal Myelopoiesis Associated with Down Syndrome (a myeloid proliferation occurring in newborns with Down syndrome). Transient Abnormal Myelopoiesis Associated with Down Syndrome is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations.;

Neoplastic status : Malignant;

ICD-O code : 9898/1;

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30/07/2025


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