Preferred Label : Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7;
NCIt synonyms : Stage IV Keratinizing Epidermoid Carcinoma of Nasopharynx; Stage IV Nasopharyngeal Keratinizing Epidermoid Carcinoma; Stage IV Keratinizing Squamous Cell Carcinoma of the Nasopharynx; Stage IV Keratinizing Squamous Cell Carcinoma of Nasopharynx; Stage IV Keratinizing Epidermoid Carcinoma of the Nasopharynx; Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma; Stage IV Nasopharyngeal Squamous Cell Carcinoma;
NCIt related terms : Stage IV Nasopharyngeal Throat Keratinizing Squamous Cell Cancer;
NCIt definition : Stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); IVB (Any T, N3,
M0); IVC (Any T, Any N, M1). T4: Nasopharyngeal cancer with intracranial extension
and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the
infratemporal fossa/masticator space. N0: No regional lymph node metastasis. N1: Nasopharyngeal
cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest
dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal
lymph nodes, 6 cm or less in greatest dimension. Midline nodes are considered ipsilateral
nodes. N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s),
6 cm or less in greatest dimension, above the supraclavicular fossa. Midline nodes
are considered ipsilateral nodes. N3: Nasopharyngeal cancer with metastasis in a lymph
node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa. Supraclavicular
zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular
region originally described by Ho. It is defined by three points: (1) the superior
margin of the sternal end of the clavicle, (2) the superior margin of the lateral
end of the clavicle, (3) the point where the neck meets the shoulder. This would include
caudal portions of levels IV and VB. All cases with lymph nodes (whole or part) in
the fossa are considered N3b. M0: No distant metastasis. M1: Distant metastasis. (AJCC
7th ed.);
Neoplastic status : Malignant;
Origin ID : C8228;
UMLS CUI : C4721432;
Automatic exact mappings (from CISMeF team)
- Disease excludes abnormal cell
- Disease may have findings
- Has associated anatomic sites
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_is_stage
- disease_mapped_to_gene
- disease_may_have_cytogenetic_abnormality
- disease_may_have_molecular_abnormality
