Preferred Label : Coagulation Factor X Human;
NCIt synonyms : Human Factor X; Human Coagulation Factor X; Coagulation FX Human; Plasma-derived Human Factor X; Human Factor X Concentrate;
NCIt related terms : Factor X human;
NCIt definition : A concentrate of the human blood coagulation Factor X (FX), derived from human plasma
obtained from healthy donors, that can be used to prevent or control bleeding episodes
in patients with hereditary FX deficiency. Upon intravenous administration of coagulation
FX human, human FX temporarily replaces the missing endogenous FX needed for effective
hemostasis. Inactive FX is converted and activated by Factor IXa, via the intrinsic
coagulation pathway, or by Factor VIIa, via the extrinsic coagulation pathway, to
the active form factor Xa (FXa), a trypsin-like serine protease. FXa associates with
Factor Va on a phospholipid surface to form the prothrombinase complex, which activates
prothrombin to thrombin in the presence of calcium ions. Thrombin then acts upon soluble
fibrinogen and Factor XIII to generate a cross-linked fibrin clot. This prevents and/or
stops bleeding and decreases activated partial thromboplastin time (aPTT) and prothrombin
time (PT). FX, a vitamin K-dependent, liver-produced serine protease, serves as the
first enzyme in the coagulation cascade to form fibrin.;
UNII : 0P94UQE6SY;
Drug name : Coagadex;
Codes from synonyms : 18870;
Origin ID : C82272;
UMLS CUI : C2826078;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
