Zofenopril - CISMeF

Preferred Label : Zofenopril;

NCIt definition : A sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zofenopril is hydrolyzed in vivo into its active form zofenoprilat. Zofenoprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zofenoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : 290ZY759PI;

InChIKey : IAIDUHCBNLFXEF-MNEFBYGVSA-N;

CAS number : 81872-10-8;

Chemical formula : C22H23NO4S2;

Details

Origin ID

C82219;

UMLS CUI

C0078836;

Automatic exact mappings (from CISMeF team)
- zofenoprilate [MeSH concept]
- zofenoprilate [MeSH Supplementary Concept]
CISMeF manual mappings
- Zofenopril (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing zofenopril (medicinal product) [SNOMED CT concept]
- Zofenopril [ICD-11 Extension code]
- Zofenopril (substance) [SNOMED CT concept]
- zofenopril [ATC Code]
- zofenopril [MeSH Supplementary Concept]
- zofenopril [MeSH concept]
Validated automatic mappings to BTNT
- zofenopril [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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