Zabicipril - CISMeF

Preferred Label : Zabicipril;

NCIt synonyms : (3S)-2-((2S)-N-((1S)-1-Carboxy-3-phenylpropyl)alanyl)-2-azabicyclo(2.2.2)octane-3-carboxylic Acid, 1-ethyl Ester;

NCIt definition : A non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zabicipril is rapidly converted in vivo by de-esterification into its active form zabiciprilat. Zabiciprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zabiciprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : 475035SS4C;

InChIKey : OMGPCTGQLHHVDU-SSXGPBTGSA-N;

CAS number : 83059-56-7;

Chemical formula : C23H32N2O5;

Details

Origin ID

C82218;

UMLS CUI

C0085048;

Automatic exact mappings (from CISMeF team)
- zabiciprilat [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- zabicipril [MeSH concept]
- zabicipril [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- zabicipril [MeSH concept]
- zabicipril [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients