Bleomycin B2 - CISMeF

Preferred Label : Bleomycin B2;

NCIt synonyms : Dehydrophleomycin D1; Phleomycin D2; Bleomycinamide, N1-(4-((aminoiminomethyl)amino)butyl)-; N1-(4-((Aminoiminomethyl)amino)butyl)bleomycinamide;

NCIt definition : One of the primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of glycopeptide bleomycin A2 and B2 isolated from Streptomyces verticillus with potential antineoplastic activity. Bleomycin B2 forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.;

UNII : M62KK37O40;

InChIKey : NBLHOLNNKJBEDC-XOGQCRKLSA-N;

CAS number : 9060-10-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 9060-10-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C55H84N20O21S2;

ChEBI ID : CHEBI:28641;

Details

Origin ID

C81672;

UMLS CUI

C0005738;

Currated CISMeF NLP mapping
- bleomycin B2 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Antibiotic [UMLS semantic type]
UMLS correspondences (same concept)
- bleomycin B2 [MeSH concept]
Validated automatic mappings to NTBT
- bleomycin [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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