Clobazam - CISMeF

Preferred Label : Clobazam;

NCIt definition : A 1,5-benzodiazepine and partial gamma-aminobutyric acid (GABA) receptor agonist, with anxiolytic, sedative, and anticonvulsant activities. Clobazam binds to a specific site, distinct from the inhibitory neurotransmitter GABA binding site, on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the opening of chloride-channels. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and a decrease in neuronal excitability.;

UNII : 2MRO291B4U;

InChIKey : CXOXHMZGEKVPMT-UHFFFAOYSA-N;

CAS number : 22316-47-8;

Drug name : Frisium; Urbanol; Onfi;

Chemical formula : C16H13ClN2O2;

ChEBI ID : CHEBI:31413;

Details

Origin ID

C81615;

UMLS CUI

C0055891;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Clobazam [MeSH Descriptor]
- Clobazam [ICD-11 Extension code]
- Clobazam (substance) [SNOMED CT concept]
- Product containing clobazam (medicinal product) [SNOMED CT concept]
- cloBAZam [LOINC component]
- clobazam [ATC Code]
- clobazam [Substance BNPC]
- clobazam [MeSH concept]
- clobazam [SNOMED Notion]
Validated automatic mappings to BTNT
- clobazam [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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