Budotitane - CISMeF

Preferred Label : Budotitane;

NCIt definition : A titanium metal complex, coordinated with asymmetric beta-diketonate ligands, with antineoplastic activity. Although the exact mechanism of action remains to be elucidated, budotitane potentially binds either to macromolecules via coordinative covalent bonds, or via intercalation between nucleic acids strands by the aromatic ring of the beta-diketonate. In addition, this agent appears to cause cardiac arrhythmias and is toxic to the liver and kidneys at higher doses. The development of budotitane was halted due to the rapid loss of its labile groups under physiological conditions.;

UNII : DV05VZD83V;

InChIKey : KAPHMPHWLCJRRK-UHFFFAOYSA-N;

CAS number : 85969-07-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 85969-07-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : 2C10H9O2.2C2H5O.Ti;

Details

Origin ID

C81555;

UMLS CUI

C0057922;

Currated CISMeF NLP mapping
- diethoxy-(1-phenyl-1,3-butanedionato)titanium (IV) [MeSH Supplementary Concept]
- diethoxy-(1-phenyl-1,3-butanedionato)titanium (IV) [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- diethoxy-(1-phenyl-1,3-butanedionato)titanium (IV) [MeSH concept]
- diethoxy-(1-phenyl-1,3-butanedionato)titanium (IV) [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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