Sobetirome - CISMeF

Preferred Label : Sobetirome;

NCIt definition : A thyroid hormone receptor isoform beta-1 liver-selective analog with antilipidemic and antiatherosclerotic activity. In animal models sobetirome reduced serum lipids, decreased cholesterol levels, and stimulated steps of reverse cholesterol transport, which promotes the reverse transport of cholesterol from atherogenic macrophages back to the liver for excretion. In humans, sobetirome lowered plasma LDL cholesterol and reduced plasma triglycerides, while its liver-selective activity helped avoid the side effects seen with many other thyromimetic agents.;

UNII : XQ31741E9Q;

InChIKey : QNAZTOHXCZPOSA-UHFFFAOYSA-N;

CAS number : 211110-63-3;

Molecule name : GC-1;

Chemical formula : C20H24O4;

Details

Origin ID

C81539;

UMLS CUI

C1135764;

Automatic exact mappings (from CISMeF team)
- GC 1 compound [MeSH concept]
- GC 1 compound [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- sobetirome [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- GC 1 compound [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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