Preferred Label : Colestolone;
NCIt definition : An antilipidemic agent based on the carbon skeleton of cholesterol. Colestolone targets
sterol regulatory element binding protein (SREBP) which reduces the transcription
of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) gene, the rate-limiting
enzyme in the sterol pathway. Colestolone is also metabolized by cells into polar
sterols, which are known to inhibit HMGCR enzymatic activity.;
UNII : 5P8396T5XF;
InChIKey : LINVVMHRTUSXHL-GGVPDPBRSA-N;
CAS number : 50673-97-7;
Chemical formula : C27H44O2;
ChEBI ID : CHEBI:61829;
Origin ID : C81532;
UMLS CUI : C2825672;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
