NCIt definition : An orally available, alpha-1 adrenoreceptor (alpha-1a) selective antagonist that can
be used to relieve symptoms of benign prostate hyperplasia (BPH). Upon administration,
silodosin selectively binds alpha-1a receptors located in the human prostate and bladder
with high affinity and blocks signaling pathways mediated by alpha-1a. Blockade of
these receptors causes smooth muscle relaxation, lowers intraurethral pressure, and
results in improved urine flow and a reduction in the symptoms of BPH, such as difficulty
with urinating, painful urination, urinary frequency and incomplete bladder emptying.
In addition, silodosin may be used to improve lower urinary tract symptoms, which
can occur after receiving radiation therapy for prostate cancer.;
UNII : CUZ39LUY82;
InChIKey : PNCPYILNMDWPEY-QGZVFWFLSA-N;
CAS number : 160970-54-7;
Drug name : Rapaflo; Urief; Rapilif; Silodyx; Urorec;