Preferred Label : Poractant Alfa;
NCIt definition : A sterile, non-pyrogenic pulmonary surfactant and extract composed of natural porcine
lung surfactant consisting of 99% polar lipids, mainly phospholipids, and 1% hydrophobic
low molecular weight proteins, including the surfactant associated proteins SP-B and
SP-C, that can be used to replace and mimic endogenous pulmonary surfactant. Upon
intratracheal administration, poractant alfa compensates for the deficiency of endogenous
lung surfactant and restores surface activity to the lungs. This reduces surface tension
at the air-liquid interface of the alveoli during ventilation and stabilizes the alveoli
against collapse at resting transpulmonary pressures. This may improve poor lung expansion,
inadequate gas exchange, and may improve oxygenation.;
UNII : KE3U2023NP;
CAS number : 129069-19-8;
Drug name : Curosurf;
Origin ID : C81353;
UMLS CUI : C0771648;
See also inter- (CISMeF)
- Semantic type(s)
- concept_is_in_subset
