Preferred Label : Human Coagulation Factor VIII/Von Willebrand Factor Complex;
NCIt synonyms : Human Coagulation Factor VIII Von Willebrand Factor Complex; von Willebrand Factor/Coagulation Factor VIII Complex Human;
NCIt related terms : Von Willebrand factor and factor VIII complex human;
NCIt definition : A human donor plasma-derived preparation containing von Willebrand factor (VWF) and
coagulation factor VIII (FVIII) that can be used to treat von Willebrand disease and
hemophilia A to control or prevent bleeding episodes. Upon administration, human coagulation
FVIII/VWF complex temporarily provides and replaces missing VWF and FVIII. VWF promotes
platelet aggregation and platelet adhesion on damaged vascular endothelium. In addition,
VWF binds to the procoagulant protein FVIII, and activated FVIII (FVIIIa) acts as
a cofactor for activated factor IX (FIXa). FIXa converts factor X (FX) into activated
factor X (FXa), which leads to the formation of thrombin and fibrin. This prevents
or control excessive bleeding.;
UNII : 5T6B772R4Q;
CAS number : 9001-27-8;
Drug name : Wilate;
Codes from synonyms : 38407;
Origin ID : C81127;
UMLS CUI : C2732016;
Semantic type(s)
- concept_is_in_subset
