Eptacog Alfa - CISMeF

Preferred Label : Eptacog Alfa;

NCIt synonyms : Recombinant Factor VIIa; Recombinant Coagulation Factor VIIa; Coagulation Factor VIIa Recombinant Human; Recombinant FVIIa; rFVIIa; Coagulation Factor VIIa Recombinant;

NCIt related terms : Factor VIIa recombinant;

NCIt definition : A recombinant form of the vitamin K-dependent glycoprotein and coagulation factor VIIa (FVIIa), that can be used for the treatment of bleeding episodes and perioperative management in patients with hemophilia, congenital Factor VII (FVII) deficiency, and Glanzmann's thrombasthenia. Upon intravenous administration, eptacog alfa temporarily replaces missing endogenous FVIIa. When complexed with tissue factor (TF), FVIIa activates coagulation Factor X (FX) to Factor Xa (FXa), as well as coagulation Factor IX to Factor IXa. Factor Xa, in complex with other factors, then converts prothrombin to thrombin. This converts fibrinogen to fibrin and leads to the formation of a hemostatic plug, thereby inducing local hemostasis and prevents bleeding.;

UNII : AC71R787OV;

CAS number : 102786-61-8;

Drug name : NovoSeven RT; Novoseven;

Codes from synonyms : 209;

Details

Origin ID

C81125;

UMLS CUI

C0795575;

Automatic exact mappings (from CISMeF team)
- recombinant FVIIa [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Eptacog alfa (substance) [SNOMED CT concept]
- Product containing eptacog alfa (medicinal product) [SNOMED CT concept]
- coagulation factor VIIa [ATC Code]
- recombinant FVIIa [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- Eptacog alfa (activated) [SMS substance]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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