" /> Moroctocog Alfa - CISMeF





Preferred Label : Moroctocog Alfa;

NCIt synonyms : Antihemophilic Factor Human Recombinant Residues 743-1636 Deleted; Antihemophilic Factor, Human Recombinant Residues 743-1636 Deleted; B-Domain Deleted Recombinant Factor VIII; AF-CC; Human Factor VIII, Recombinant B-Domain Deleted; BDDrFVIII;

NCIt related terms : Factor VIII recombinant;

NCIt definition : A recombinant form of human endogenous antihemophilic factor (rAHF) (coagulation factor VIII) produced by recombinant DNA technology, in which the B-domain is deleted (BDDrFVIII), that can be used to treat and control bleeding episodes in hemophilia A (congenital factor-VIII deficiency). Upon administration, moroctocog alfa temporarily replaces the missing coagulation factor VIII, which binds factor IXa. Factor X is then converted to factor Xa. This facilitates the clotting cascade by converting prothrombin to thrombin, and leads to the conversion of fibrinogen to fibrin, and thus clot formation. This normalizes the activated partial thromboplastin time (aPTT) that is needed for effective hemostasis. Patients with hemophilia A lack factor VIII, a protein needed for normal clotting of the blood. B-domain has no known biological function.;

UNII : 113E3Z3CJJ;

CAS number : 284036-24-4;

Drug name : ReFacto; Xyntha;

Codes from synonyms : 208;

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09/05/2025


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