Preferred Label : Ipamorelin;
NCIt synonyms : Aib-His-D-2-Nal-D-Phe-Lys-NH2; 2-Methylalanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenylalanyl-L-lysinamide;
NCIt definition : A pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and a ghrelin mimetic with growth hormone
(GH) releasing activity. Ipamorelin mimics ghrelin and binds to the ghrelin receptor
(or GH secretagogue receptor, GHSR) in the brain, thereby selectively stimulating
the release of GH from the pituitary gland. This results in increased plasma GH levels,
which would affect many biological processes. Besides its presence in the brain, GHSR
can also be found in the gastrointestinal tract, heart, lung, liver, kidney, pancreas,
adipose tissue and immune cells. Unlike other GH releasing peptides, ipamorelin only
stimulates GH release in a manner very similar to that of growth hormone releasing
hormone.;
UNII : Y9M3S784Z6;
InChIKey : NEHWBYHLYZGBNO-BVEPWEIPSA-N;
CAS number : 170851-70-4;
Chemical formula : C38H49N9O5;
Origin ID : C81120;
UMLS CUI : C0757797;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
