NCIt definition : The sulfate form of cefquinome, a semisynthetic, broad-spectrum, fourth-generation
aminothiazolyl cephalosporin with antibacterial activity. Cefquinome binds to and
inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the
bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling
the bacterial cell wall and in reshaping the cell wall during growth and division.
Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary
for bacterial cell wall strength and rigidity. This results in the weakening of the
bacterial cell wall and causes cell lysis.;