NCIt definition : A sterile suspension composed of an extract of bovine pulmonary surfactant with surfactant
activity. Calfactant contains phospholipids, neutral lipids, and hydrophobic surfactant-associated
proteins B (SP-B) and C (SP-C). Upon intratracheal administration, this agent, mimicking
endogenous pulmonary surfactant, lines the alveoli and smallest bronchioles, keeping
alveoli open during expiration by lowering surface tension. Resulting improvements
in lung compliance and respiratory gas exchange may lead to improvements in ventilation
and oxygenation.;