NCIt definition : The sodium salt form of ditiocarb, an active metabolite of disulfiram, with potential
antineoplastic and chemosensitizing activities. Upon administration, ditiocarb sodium
may form a complex with copper (Cu), a metal that selectively accumulates in cancer
cells. This complex may inhibit the nuclear factor-kB (NF-kB) pathway activated by
tumor hypoxia, thereby inhibiting tumor cell growth. It may also reverse chemoresistance
and enhance cytotoxicity of other chemotherapeutic agents.;