Preferred Label : Vepoloxamer;
NCIt synonyms : Purified Poloxamer 188; Poloxamer-188;
NCIt related terms : POLOXAMER 188;
NCIt definition : A purified form of the non-ionic polyoxypropylene-based copolymer poloxamer 188 comprised
of a hydrophobic core with hydrophilic side chains, with cytoprotective, hemorrheologic,
anti-inflammatory, anti-thrombotic and fibrinolytic activities. Although the exact
mechanism of action is not fully elucidated, upon intravenous administration, the
hydrophobic polyoxypropylene core of vepoloxamer reversibly adheres to hydrophobic
sites of damaged cell membranes, thereby fully covering the damaged sites. This prevents
the attachment of other hydrophobic molecules, cell leakage of contents, such as ions,
and restores the integrity of the damaged cell. Binding of vepoloxamer to damaged
cells in the blood vessel walls, prevents cell aggregation and improves blood flow.
By occupying damaged sites, this agent also prevents inflammatory processes, inhibits
thrombosis, and induces fibrinolysis. As the hydrophobic region of the lipid cell
membrane is not exposed in healthy cells, vepoloxamer does not adhere to healthy cells.;
UNII : LQA7B6G8JG;
CAS number : 691397-13-4;
Molecule name : MST-188;
Chemical formula : C4H10O3(C2H4O)n(C3H6O)n;
ChEBI ID : CHEBI:53515;
Origin ID : C80936;
UMLS CUI : C4053876;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
