Preferred Label : Ricin;
NCIt synonyms : Ricinus Communis Agglutinin II;
NCIt definition : A phytotoxin and lectin comprised of a homodimer of ricin toxin A and B chains derived
from the seeds of Ricinus communis, the castor oil plant, with protein synthesis inhibitory
activity and extremely high cytotoxicity. Following ingestion, inhalation or injection
of ricin, the B chain binds to complex carbohydrates containing either terminal N-acetylgalactosamine
or beta-1,4-linked galactose residues on the surface of cells. Subsequently, the ricin
A/B heterodimer is internalized and undergoes retrograde transport to the endoplasmic
reticulum (ER). In the ER, the A chain, which has enzymatic activity that is sterically
hindered by the B chain, is proteolytically released from the heterodimer by protein
disulfide isomerase. In the ER, the free A chain has N-glycosidase activity that cleaves
28S rRNA. This enzymatic cleavage disrupts the ribosome, halts protein synthesis,
and can lead to cell death. The extreme cytotoxicity of ricin makes it an attractive
candidate for artificial fusion with binding proteins to create cell-type-specific
toxins.;
Alternative definition : CDISC: The biotoxin ricin.;
UNII : U6E7R9OE4R;
CAS number : 9009-86-3;
NSC code : 9902;
Codes from synonyms : NSC0009902;
Origin ID : C809;
UMLS CUI : C0035569;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Ricin [ICD-11 Extension code]
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
