NCIt definition : A pyrimido-pyrimidine with antitumor activity. BIBX 1382 inhibits the intracellular
tyrosine kinase domain of the Epidermal Growth Factor Receptor (EGFR) thus specifically
reversing the aberrant enzymatic activity from overexpressed and constitutively activated
EGFR, and subsequently inhibiting cell proliferation and inducing cell differentiation.;
Alternative definition : NCI-GLOSS: A drug that may inhibit tumor cells from multiplying. It is being studied
for its ability to treat cancer.;